CAR-T 细胞疗法是癌症治疗领域的一项重大突破，也是基因工程细胞作为治疗手段的有力证明。除了已获批准用于白血病等血液类癌症治疗以外，CAR-T 细胞疗法还在实体瘤、自身免疫疾病以及组织再生方面也展现出巨大潜力。 然而，大量临床试验显示，CAR-T 细胞 ...

为解决CAR-T细胞功能障碍导致的治疗失败问题，奥地利研究团队开发了CRISPR筛选平台CELLFIE，通过全基因组筛选发现RHOG和FAS基因敲除可显著增强CAR-T细胞抗肿瘤活性，并在多种体内模型中验证其协同增效作用，为优化细胞免疫疗法提供了重要资源。 在癌症治疗领域 ...

麻省总医院布莱根分校（Mass General Brigham）和麻省理工学院-哈佛大学布罗德研究所（Broad Institute）的研究人员发现了可以提高嵌合抗原受体（CAR）-T细胞疗法疗效的基因修饰。CAR-T细胞疗法是一种利用经过修饰的患者T细胞靶向癌症的免疫疗法。该研究利用CRISPR ...

When the genome-editing tool CRISPR is thought of as a potential medicine, the targets that first come to mind are diseases like sickle cell or other conditions caused by particular mutations. Use ...

The gene-editing technique known as CRISPR is promising to revolutionize medicine. Some researchers are trying to help make it available for people with very rare genetic disorders. A gene-editing ...

The practice of genetic modification is as old as humanity. For thousands of years, humans have bred crops, livestock and even pets that possess desirable traits. This selective process, which alters ...

With such striking effects, many scientists see modulating the microbiomes as a promising avenue for improving human health and wellbeing. In recent years, researchers have shown that tweaking the ...

Banas is associate director of research at the Gene Editing Institute at ChristianaCare, where Kmiec is founder and executive director. The medical promise of CRISPR gene editing can be seen most ...

CRISPR, the gene-editing technology that has revolutionized biological research, is finally available as a medical treatment with regulatory approval. On December 8 the U.S. Food and Drug ...

CRISPR Therapeutics (CRSP) just announced that its SyNTase gene editing technology will be featured in an oral presentation at the ESGCT 2025 Congress. This marks the first major public unveiling of ...